Vellareddy Anantharam Selected Research

Neurodegenerative Diseases (Neurodegenerative Disease)

9/2022	Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
1/2022	Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.
12/2019	Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.
1/2019	Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.
1/2018	Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.
7/2017	Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.
1/2017	Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases.
1/2017	Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.
8/2014	Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.
1/2014	Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease.

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Vellareddy Anantharam Research Topics

Disease

44	Parkinson Disease (Parkinson's Disease) 01/2024 - 03/2003
17	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 08/2005
16	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2022 - 03/2003
7	Neuroinflammatory Diseases 01/2023 - 04/2012
7	Inflammation (Inflammations) 01/2022 - 11/2009
5	Synucleinopathies 01/2021 - 01/2017
5	Scrapie 01/2020 - 09/2006
5	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2017 - 09/2006
4	Parkinsonian Disorders (Parkinsonism) 01/2021 - 07/2017
4	Nervous System Diseases (Neurological Disorders) 01/2018 - 04/2005
3	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2022 - 07/2017
3	Gliosis 11/2020 - 01/2018
3	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 01/2017
2	Dysbiosis 01/2022 - 01/2022
2	Infections 01/2022 - 01/2014
2	Status Epilepticus (Complex Partial Status Epilepticus) 11/2020 - 01/2020
1	Clostridium Infections 01/2022
1	Endotoxemia 08/2020
1	Brain Injuries (Brain Injury) 01/2020
1	Seizures (Absence Seizure) 01/2020
1	Lewy Body Disease (Lewy Body Dementia) 01/2020
1	Dementia (Dementias) 01/2019
1	Pathologic Processes 01/2019
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2019
1	Hypoxia (Hypoxemia) 01/2018
1	Proteostasis Deficiencies 01/2017
1	Cardiomyopathies (Cardiomyopathy) 01/2017
1	Movement Disorders (Movement Disorder) 01/2017
1	Insulin Resistance 01/2017
1	Cognitive Dysfunction 01/2017

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 09/2022 - 08/2005
13	ManganeseIBA 12/2019 - 04/2005
11	SynucleinsIBA 09/2022 - 02/2011
10	Phosphotransferases (Kinase)IBA 01/2021 - 08/2005
7	Protein Kinases (Protein Kinase)IBA 01/2016 - 11/2006
6	acetovanillone (apocynin)IBA 01/2021 - 10/2012
6	PrionsIBA 01/2020 - 09/2006
5	CytokinesIBA 01/2021 - 11/2009
5	Protein Kinase C-deltaIBA 01/2021 - 08/2005
5	InflammasomesIBA 01/2021 - 01/2017
5	Biomarkers (Surrogate Marker)IBA 12/2020 - 04/2015
5	MetalsIBA 12/2019 - 06/2010
5	AntioxidantsIBA 01/2018 - 09/2006
4	UbiquitinIBA 08/2009 - 09/2006
4	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2009 - 09/2006
3	Neuroprotective AgentsIBA 01/2022 - 09/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 03/2002
3	EnzymesIBA 01/2021 - 11/2009
3	alpha-SynucleinIBA 01/2021 - 09/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2020 - 04/2012
3	Prion ProteinsIBA 10/2011 - 09/2006
2	Metformin (Glucophage)FDA LinkGeneric 01/2024 - 01/2022
2	Histones (Histone)IBA 01/2023 - 12/2014
2	RotenoneIBA 01/2022 - 01/2017
2	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 09/2006
2	ChemokinesIBA 11/2020 - 01/2020
2	Interleukin-6 (Interleukin 6)IBA 11/2020 - 08/2020
2	Isoflurophate (DFP)FDA Link 11/2020 - 01/2020
2	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2018
2	Protein Kinase CIBA 01/2017 - 09/2007
2	Protein Isoforms (Isoforms)IBA 10/2011 - 09/2007
2	NeurotoxinsIBA 10/2008 - 06/2007
2	DieldrinIBA 10/2008 - 08/2005
2	Caspase 3 (Caspase-3)IBA 11/2006 - 03/2002
1	Heavy MetalsIBA 09/2022
1	HerbicidesIBA 09/2022
1	PesticidesIBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Activating Transcription Factor 4IBA 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Inositol (Myoinositol)IBA 01/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2021
1	salubrinalIBA 01/2021
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2021
1	EndoribonucleasesIBA 01/2021
1	Interleukin-17 (Interleukin 17)IBA 11/2020
1	InterleukinsIBA 11/2020
1	Cholinergic Agents (Cholinergics)IBA 11/2020
1	LeptinIBA 11/2020
1	Interleukin-2 (IL2)IBA 11/2020
1	NitritesIBA 11/2020
1	Blood Proteins (Serum Proteins)IBA 11/2020
1	AcetylcholinesteraseIBA 11/2020
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2020
1	src-Family KinasesIBA 08/2020
1	AntibodiesIBA 02/2020
1	3-nitrotyrosineIBA 01/2020
1	Atropine FDA LinkGeneric 01/2020
1	Diazepam (Valium)FDA LinkGeneric 01/2020
1	Formaldehyde (Formol)FDA Link 01/2020
1	OximesIBA 01/2020
1	ParaffinIBA 01/2020
1	Cholecystokinin (Pancreozymin)IBA 01/2019
1	Blood Glucose (Blood Sugar)IBA 01/2017
1	QuercetinIBA 01/2017
1	NAD (NADH)IBA 01/2017
1	Insulin-Like Growth Factor Binding Protein 2IBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017

Therapy/Procedure

4	Therapeutics 01/2020 - 08/2014